We understand a lot about organelles in their native organisms, but we cannot yet create any custom-made organelle for any biotechnological purpose. Like Richard Feynman said, "What I cannot create, I do not understand", so in a build-to-understand approach, we are tackling synthetic organelle biogenesis to understand the rules that guide novel organelle creation. After the revolution of DNA and proteins, organelles are the next frontier of Engineering Biology.
Lipid transporters facilitate lipid movement through biological membranes and are therefore involved in multiple biological processes. They hold the key to a deeper understanding of nature and promise for biotechnological applications. We are tackling challenges associated to understading their mechanisms of action and the relationship between ligand specificity and structure.
A few genetic mutations can have drastic effects on membranes, which could be exploited for biotechnological applications such as supplementing synthetic organelle creation and biomanufacturing. We are tackling challenges associated to understanding and leveraging biological membranes.
We are leveraging our research for biomanufacturing, that is, making valuable chemicals such as pharmaceuticals, flavours and fragrances, fuels, and agrichemicals, from renewable carbon towards sustainability.